More than 12,000 healthcare executives, investors, clinicians, and founders will descend on Las Vegas this month for HLTH USA 2026, running November 15 to 18 at The Venetian Expo Center. With 950+ sponsors and exhibitors and roughly 4,400 C-suite attendees expected, the event has become one of the industry's most important venues for unveiling the technologies reshaping how healthcare is delivered, measured, and paid for.
Organizers have billed this year's show as the arrival of "intelligent healthcare," and the agenda reflects it. Artificial intelligence has moved beyond the pilot phase and is being built directly into the infrastructure of care, from the foundation models powering clinical tools to the data platforms that make patient records usable in the first place.
From the world's largest AI labs to emerging startups, several companies stand out as particularly interesting to watch at HLTH 2026.
1. OpenAI — Booth 2304
Few companies have moved into healthcare as aggressively over the past year as OpenAI.
In January the company introduced ChatGPT Health, a dedicated space inside its flagship product that lets users securely connect medical records, lab results, and wellness apps, and the feature rolled out broadly to US users over the summer. OpenAI says more than 230 million people already ask ChatGPT health and wellness questions every week.
The company has been building out its enterprise side just as quickly. OpenAI for Healthcare is rolling out at major health systems including HCA Healthcare, Cedars-Sinai, and Memorial Sloan Kettering, and in April the company released a free ChatGPT for Clinicians tier for verified doctors, nurse practitioners, and pharmacists.
With Ashley Alexander, OpenAI's VP of Product for Health, on the HLTH 2026 speaker lineup, the company's healthcare roadmap is likely to be one of the most closely watched conversations of the week.
2. Anthropic (speaker lineup, no booth)
Anthropic has been building a healthcare business of its own at a remarkable pace.
The company launched Claude for Life Sciences in October 2025, connecting its AI models to research platforms such as Benchling and PubMed, and followed in January with Claude for Healthcare, a HIPAA-ready offering built for providers, payers, and patients that arrived just days after OpenAI's announcement. Organizations including Banner Health, Novo Nordisk, and Genmab have already put Claude to work.
The life sciences effort has since expanded into clinical trial operations and regulatory workflows, and the company has stood up an internal drug discovery program focused on neglected diseases.
Dr. Syed Mohiuddin, Anthropic's Head of Healthcare, is confirmed for the HLTH 2026 speaker lineup, which puts both frontier AI labs on the same stage in Las Vegas just as their healthcare strategies come into direct competition.
3. Wolters Kluwer — Booth 3021
Clinical intelligence provider Wolters Kluwer is sponsoring and exhibiting at HLTH 2026, where it plans to show how its widely used clinical reference content is being adapted for the AI era.
The company will be demonstrating UpToDate Expert AI, which brings governed, evidence-based AI into clinical decision-making, alongside a new UpToDate Expert AI API that lets digital health companies embed conversational, AI-generated answers grounded in UpToDate's clinical content directly into their own products. Its Medi-Span drug data business adds a structured medication intelligence layer underneath those tools.
As AI moves deeper into clinical workflows, Wolters Kluwer is making the case that healthcare organizations need validation and clinical governance to separate useful innovation from ungoverned risk, a message likely to resonate with the health system executives walking the floor.
4. Omada Health — Booth 2221
Virtual care provider Omada Health returns to HLTH 2026 as a sponsor and exhibitor, inviting attendees to step into what it calls the "Omadaverse" at Booth 2221.
The company delivers virtual care programs for chronic conditions including diabetes, prediabetes, hypertension, and musculoskeletal issues, pairing members with dedicated care teams and publishing its clinical outcomes in peer-reviewed journals. Omada went public on the Nasdaq in June 2025 as part of a small wave of digital health IPOs that reopened the market for the sector.
With GLP-1 medications reshaping how employers and health plans approach chronic disease, companion care programs like Omada's have become some of the most closely watched businesses in digital health. The company says it will spend the week sharing updates on its virtual care and population health work and meeting with executive leaders on the floor.
5. WHOOP (speaker lineup, no booth)
Wearable maker WHOOP arrives in Las Vegas in the middle of a deliberate transformation from fitness tracker to health platform.
The company raised a $575 million Series G at a $10.1 billion valuation earlier this year and has spent the past 18 months moving into medical territory. Its WHOOP MG band pairs an FDA-cleared ECG with blood pressure insights, its Advanced Labs service combines clinician-reviewed blood testing with continuous wearable data, and in July the company hired former FDA advisor Dr. Ami Bhatt as its chief medical officer.
The push brought friction with regulators along the way, as WHOOP spent a year in a public dispute with the FDA over whether its blood pressure feature constituted a medical device. The standoff ended this year after the agency issued new guidance for wellness wearables and closed its warning letter, a resolution that cleared a path for the entire consumer health category.
Founder and CEO Will Ahmed is on the HLTH 2026 speaker lineup, where the blurring line between consumer wearables and clinical care is certain to be a running theme.
6. xCures — Booth 4421
Oakland-based xCures arrives at HLTH 2026 on the momentum of a $46 million Series B closed in June, which brought the company's total funding past $76 million.
xCures assembles and structures patient medical records into decision-ready data, work it markets as a clinical clarity engine. The company says it has processed more than 400 million records from over 550,000 care locations.
That kind of data infrastructure has taken on new urgency as AI tools spread across healthcare. The quality of the underlying patient record increasingly determines whether those tools deliver, and xCures has been working on the problem since its founding in 2018, when it began assembling complete treatment histories for cancer patients.
A peer-reviewed validation study published in September in AI in Precision Oncology put hard numbers behind the approach. The company's LLM-based extraction reached 95% accuracy across medications, radiation, and surgical procedures. The platform is HITRUST certified, a security credential health systems and payers increasingly expect from AI vendors.
With CEO Mika Newton on the ground for the week, expect xCures to be in the middle of the show's defining conversation about clinical data and AI.
7. Cityblock Health (speaker lineup, no booth)
Few companies sit closer to the policy crosscurrents shaping this year's show than Cityblock Health, the value-based care provider built for Medicaid and dually eligible patients.
Spun out of Alphabet's Sidewalk Labs in 2017, Cityblock delivers integrated primary care, behavioral health, and social services to more than 100,000 members across ten-plus states, working alongside national and regional Medicaid health plans. In August the company acquired rural care provider Homeward and raised $116 million to extend its model beyond cities, and it has been building out AI-powered care coordination for members with long-term care needs.
With Medicaid budgets under pressure in Washington and in statehouses across the country, co-founder and CEO Dr. Toyin Ajayi takes the HLTH stage at a moment when the economics of caring for the program's roughly 70 million enrollees have rarely been more contested.
8. Thrive Global (speaker lineup, no booth)
Thrive Global, the behavior change company Arianna Huffington founded in 2016 after leaving The Huffington Post, rounds out the list.
The company sells science-backed behavior change programs to large employers, and in 2024 it joined with the OpenAI Startup Fund to launch Thrive AI Health, a venture building a hyper-personalized AI health coach aimed at chronic disease. The coach centers on five daily behaviors with outsized influence on health outcomes: sleep, food, movement, stress management, and connection.
Huffington has long argued that what people do between doctor visits shapes their health more than anything that happens in the exam room, and her place on the HLTH 2026 speaker lineup gives her one of the week's bigger platforms to make that case.
A Preview of Healthcare's Intelligent Era
Taken together, the companies heading to HLTH 2026 show how thoroughly AI has moved into every layer of healthcare, from the foundation models answering patient questions to the data platforms assembling the records those models depend on, and from the care providers coordinating treatment for complex populations to the wearables carrying monitoring out of the clinic and onto the wrist.
The other thread running through the lineup is trust. Nearly every company on this list has spent the past year accumulating the credentials that let AI operate inside regulated healthcare, whether through HIPAA-ready enterprise offerings, security certifications, or hard-won clarity from the FDA on where wellness ends and medicine begins.
For the healthcare leaders arriving at The Venetian this month, the companies exhibiting and speaking in Las Vegas offer an early look at the technologies that may define the industry's next chapter.